三种灌注药物预防膀胱癌术后复发的疗效观察

探讨几种常用灌注药物预防膀胱癌术后复发的疗效。方法：将９３例患者分为３组，第一组用丝裂霉素Ｃ２０ｍｇ，第二组用卡介苗６０ｍｇ，第三组用ＢＣＧ６０ｍｇ加白细胞介素－２（ＩＬ－２）１００００ｕ行膀胱灌注。结论丝裂霉素Ｃ、ＢＣＧ及ＢＣＧ加ＩＬ－２膀胱灌注预防膀胱癌术后复发，疗效十分肯定，其中ＢＣＧ加ＩＬ－２灌注效果更好。

Clinical results of three different intravesical instillation agents for the prevention of postoperative recurrence of bladder tumor

Purpose:To study the clinical results of three different intravesical instillation agents for the prevention of postoperative recurrence of bladder tumor. Methods:93 cases of patients with bladder cancer were devided into three groups: group 1 received 20 mg MMC intravesical instillation postoperatively, group 2 received 60 mg BCG, and group3 received a combination of 10 000 unites of IL-2 and 60 mg BCG. Follow up ranged from 6 to 72 months, with a mean time of 30.5 months. Results: The recurrence rate was 24.1 %(7/29) in group l, 20.0 %(6/30) in group 2, and 8.8%(3/34) in group 3. The defference between group 3 and the other 2 groups is of great significance( P < 0.01 ). Conclusions:The results revealed that all the three different intravesical instillation agents are effecticve for preventing postoperative recurrence of bladder tumor, and that the combination of 10 000 unites of IL-2 and 60 mg BCG are more effective.