| 不同中药注射剂对脑梗死大鼠急性期治疗作用的研究 |
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| 引用本文： | 杜玉玲,李文涛,周飞.不同中药注射剂对脑梗死大鼠急性期治疗作用的研究[J].上海中医药杂志,2010(2):61-63. |
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| 作者姓名： | 杜玉玲 李文涛 周飞 |
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| 作者单位： | 复旦大学附属金山医院中医科;上海市中医医院神经内科;上海市针灸经络研究中心; |
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| 摘 要： | 目的观察不同中药注射剂对脑梗死大鼠急性期治疗的作用。方法采用Longa线栓法制作脑梗死大鼠模型。实验大鼠按照要求随机分为5组，即假手术组、模型对照组、黄芪组、丹参组、醒脑静组。分别予以腹腔注射0．9％NaCl溶液、0．9％NaCl溶液、黄芪注射液、丹参注射液、醒脑静注射液。观察比较各组大鼠的死亡率、神经功能缺损评分和脑组织梗死体积。结果各组24h死亡率较模型组显著减少，但2d时只有丹参组死亡率较模型组减少，差异有统计学意义（P〈0．01），其他各组和模型组无明显差异。丹参组3d后神经功能缺损评分较模型组显著改善，醒脑静及黄芪组和模型组比较无明显差异。丹参组脑梗死面积较模型组显著减少，醒脑静和黄芪组有一定减轻，但无显著差异。结论不同中药注射剂用于脑梗死急性期的治疗，对于降低早期死亡率均有一定功效。而在改善神经功能和减少梗死面积方面，以丹参注射液治疗则更具优势。
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| 关 键 词： | 脑梗死 黄芪注射液 丹参注射液 醒脑静注射液 实验研究 |
Treatment of acute cerebral infarction in rats by different herbal injections |
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| DU Yu-ling LI Wen-tao ZHOU Fei.Treatment of acute cerebral infarction in rats by different herbal injections[J].Shanghai Journal of Traditional Chinese Medicine,2010(2):61-63. |
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| Authors: | DU Yu-ling LI Wen-tao ZHOU Fei |
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| Institution: | DU Yu-ling1 LI Wen-tao2 ZHOU Fei31.Jinshan Hospital Affiliated to Fudan University,Shanghai2.Shanghai Municipal Hospital of Traditional Chinese Medicine3.Shanghai Research Center of Acupuncture & Meridian |
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| Abstract: | Objective To observe the effects of different herbal injections on acute cerebral infarction.Methods The rat model of cerebral infarction was made with suture embolic method.The rats were divided into five groups:sham group was intraperitoneally injected with saline injection and the other four groups were intraperitoneally injected respectively with "Huangqi Injection","Danshen Injection","Xingnaojing Injection" and saline injection.The mortality,neural deficit score,and brain infarction volume were observ... |
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| Keywords: | Cerebral infarction "Huangqi Injection" "Danshen Injection" "Xingnaojing Injection" experimental study |
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