丹参中二氢异丹参酮Ⅰ的结构

自丹参注射液及与之有关的部位中分离得到十个结晶性物质,经化学方法及光谱分析,将其中八个结晶性物质(晶Ⅰ～晶Ⅶ和晶Ⅹ)分别鉴定为黄芩甙、β-谷甾醇、隐丹参酮、熊果酸、β-谷甾醇-D-葡萄糖甙、原儿茶醛、异阿魏酸和二氢丹参酮Ⅰ。黄芩甙、熊果酸、β-谷甾醇-D-葡萄糖甙和异阿魏酸四种成分是首次从丹参中提得。另二个未知结构的结晶性物质,晶Ⅷ已确定其结构,命名为二氢异丹参酮Ⅰ,是首次从植物中被发现,晶Ⅸ的化学结构尚在测定中。

STRUCTURE OF DIHYDROISOTANSHINONE I OF DANSHEN

Dan-Shen, the root of Salvia miitiorrhiza Bunge, is a well-known Chinese traditional drug used for treatment of various kinds of diseases including coronary disorders. For the exploration of the active principles, the chemical components of this drug were studied and ten crystalline compounds were isolated. According to chemical analysis and spectral data, eight crystalline compounds were identified as Baicalin, β-Sitosterol, Cryptotanshinone, Ursolic acid, Doursterol, Protocatechuic aldehyde, Isoferulic acid and Dihydrotanshinone I. Baicalin, Ursolic acid, Doursterol and Isoferulic acid were isolated for the first time from this plant. Besides, two unknown components were also obtained, one of which, with the structure of (Ⅷ), has been deduced from spectral data as well as by conversion into known component (dihydrotanshinone Ⅰ). It was named dihydroisotanshinone Ⅰ.