慢性腹泻肠黏膜结构和屏障功能的变化

目的 探讨慢性腹泻患者肠黏膜结构和屏障功能的变化.方法 对33例慢性腹泻患者和30名健康志愿者行结肠镜检查,并在镜下取回肠末端和回盲部黏膜各3块,光镜下观察肠黏膜的组织结构,同时测定血浆内毒素水平,以评价肠黏膜屏障功能.结果 慢性腹泻患者光镜下可见回肠末端有绒毛顶端上皮细胞水肿、脱落,但与健康志愿者无明显差异(P>0.05);回盲部可见被覆上皮细胞明显水肿、脱落和破溃,甚至被覆上皮细胞完全脱落,与健康志愿者有明显差异(P<0.05).慢性腹泻患者和健康志愿者血中内毒素含量无统计学差异(P>0.05).结论 慢性腹泻患者可能存在结肠黏膜屏障损害.

Alterations of Intestinal Mucosa Structure and Barrier Function in Chronic Diarrhea

Objective To explore the alterations of intestinal mucosa structure and barrier function in chronic diarrhea.Methods 33 chronic diarrhea patients and 30 healthy volunteers were taken coloscopy,and got 3 pieces mucosa in terminal ileum and ileocecal junction each.The intestinal mucosa structure was detected by histopathological examination with light microscope.Gut barrier dysfunction was evaluated by detecting serum endotoxin.Results Endothelial cells in top of villi of terminal ileum were hydropsia,defluxion in chronic diarrhea patients,but there was not significant difference with healthy volunteers(P>0.05).Covering epithelium cells in ileocecal junction obviously hydropsia,defluxion and defeated,even defluxion fully,there was significant difference with healthy volunteers(P<0.05).And there was not significant difference in serum endotoxin between chronic diarrhea and healthy volunteers(P>0.05).Conclusion Chronic diarrhea maybe exist colon barrier dysfunction.