Major Histocompatibility Complex Haplotype Is Associated with Postherpetic Pain in Mice |
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Authors: | Sato-Takeda Masako MD PhD; Takasaki Ichiro PhD; Takeda Kenji MD PhD; Sasaki Atsushi
; Andoh Tsugunobu PhD; Nojima Hiroshi PhD#; Shiraki Kimiyasu MD PhD; Kuraishi Yasushi PhD; Hanaoka Kazuo MD PhD; Tokunaga Katsushi PhD
; Yabe Toshio PhD |
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Institution: | Sato-Takeda, Masako M.D., Ph.D.*; Takasaki, Ichiro Ph.D.†; Takeda, Kenji M.D., Ph.D.‡; Sasaki, Atsushi§; Andoh, Tsugunobu Ph.D.∥; Nojima, Hiroshi Ph.D.#; Shiraki, Kimiyasu M.D., Ph.D.**; Kuraishi, Yasushi Ph.D.††; Hanaoka, Kazuo M.D., Ph.D.‡‡; Tokunaga, Katsushi Ph.D.§§; Yabe, Toshio Ph.D.∥∥ |
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Abstract: | Background: Postherpetic neuralgia is one of the major complications of herpes zoster caused by the reactivation of varicella-zoster virus and is characterized by severe pain. The authors previously showed the association of a human major histocompatibility complex (MHC) haplotype with postherpetic neuralgia. This study was performed to experimentally confirm the role of MHC haplotype in the development of postherpetic pain using a mouse model of postherpetic pain, which corresponds to postherpetic neuralgia. Methods: BALB/c mice (MHC haplotype: H-2d), C57BL/6 mice (MHC haplotype: H-2b), and BALB/b mice, a congenic BALB/c strain with H-2b, were used. Herpes simplex virus type I was transdermally inoculated on the hind paw. Unilaterally zosteriform skin lesion and pain-related responses (acute herpetic pain) were caused, and some mice showed pain-related responses (postherpetic pain) after the cure of skin lesions. Herpes simplex virus type I antigen and CD3-positive cells were immunostained in the dorsal root ganglion in the acute phase. Results: The incidence (78%) of postherpetic pain in C57BL/6 mice was significantly higher than that (35%) in BALB/c mice (P = 0.004, odds ratio = 6.7). Furthermore, the incidence of postherpetic pain in BALB/b (H-2b) was similar to that in C57BL/6. Herpes simplex virus type I antigen-positive cells were less in the dorsal root ganglion of C57BL/6 mice than that of BALB/c mice. CD3-positive T cells were more in the dorsal root ganglion of C57BL/6 mice than BALB/c mice. |
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