卡介菌多糖核酸预防慢性阻塞性肺病急性加重的作用研究

目的　探讨卡介菌多糖核酸对慢性阻塞性肺病患者急性加重的预防作用及其机制。方法　将 6 0例稳定期慢性阻塞性肺病患者随机分为治疗组和对照组 ,治疗组 36例接受卡介菌多糖核酸 0 .5 mg肌肉注射 ,隔日1次 ,共 18次 ;二组患者均观察 6个月 ,每两周门诊随访 1次 ,进行临床情况评价 ,治疗组于治疗前、治疗后 3个月及 6个月检查血清 Ig A、Ig G、Ig M、CD3、CD4和 CD8水平。结果　治疗组患者发生感染人数和感染天数均明显低于对照组 (P<0 .0 5 ) ,治疗后患者血 CD4及 CD4/ CD8比值明显升高 (P<0 .0 5 )。结论　卡介菌多糖核酸通过增强细胞免疫功能 ,具有明显的预防慢性阻塞性肺病急性加重的作用

The Prophylactic Effect of BCG Polysaccharides Nucleic Acid on the Acute Attack of Chronic Obstructive Pulmonary Disease

Objective To investigate the prophylactic effect of BCG polysaccharides nucleic acid (BCG PSN) on patients with chronic obstructive pulmonary disease and inquire about the mechanism thereof. Methods Sixty patients with chronic obstructive pulmonary disease were divided into two groups. In the treatment group, 36 patients received BCG PSN 0.5mg intramuscular injection, quaque die alterna, for 18 times. All patients revisited the hospital every 2 weeks and were followed up for 6 months. The number and days of patients with acute attack in 3 and 6 months were assessed. In the treatment group, the blood samples were collected before treatment and 3 and 6 months after treatment for the measurement of the blood IgA, IgG, IgM, CD 3, CD 4 and CD 8. Results The number and days of patients with acute attack in the treatment group were significantly lower than those in the control group. After the treatment by BCG PSN, blood CD 4 and CD 4/CD 8 were significantly increased. Conclusion BCG PSN increases the patient's cellular immunocompetence and thus serves as a good protection against the acute attack of chronic obstructive pulmonary disease.