| 抗呆合剂对小鼠脑缺血再灌注模型脑内LPO、SOD及海马CA1区细胞的影响 |
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| 引用本文： | 唐一鹏,赵树民,孙承琳,贾绪东,洪庆涛,胡京红.抗呆合剂对小鼠脑缺血再灌注模型脑内LPO、SOD及海马CA1区细胞的影响[J].北京中医药大学学报,1998(6). |
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| 作者姓名： | 唐一鹏 赵树民 孙承琳 贾绪东 洪庆涛 胡京红 |
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| 作者单位： | 北京中医药大学中西医结合研究所!北京100029 |
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| 基金项目： | 国家中医药管理局资助课题! (No .9512 10 ) |
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| 摘 要： | 研究采用小鼠反复脑缺血合并低血压模型 ,发现 7d时其脑内过氧化脂质(LPO)含量增高 ,SOD活力降低 ;1 0d时 ,海马CA1区神经元数量明显减少。抗呆合剂可对抗这种变化 ,减轻脑缺血再灌损伤 ,表明抗呆合剂的脑保护作用部分源于其自由基清除作用。
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| 关 键 词： | 抗呆合剂 脑缺血再灌注 LPO SOD 海马CA1区 |
Effects of Kangdai Mixture on LPO, SOD and the Cells in Hippocampal CA1 Region in Cerebral Ischemic Mice Treated by Re perfusion |
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| Tang Yipeng ,Zhao Shumin,Sun Chenglin,et al..Effects of Kangdai Mixture on LPO, SOD and the Cells in Hippocampal CA1 Region in Cerebral Ischemic Mice Treated by Re perfusion[J].Journal of Beijing University of Traditional Chinese Medicine,1998(6). |
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| Authors: | Tang Yipeng Zhao Shumin Sun Chenglin |
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| Abstract: | The cerebral ischemic and hypotensive mice treated by re perfusion were used to study the effects of Kangdai mixture (KM) on LPO, SOD and CA1 cells. The results showed that on the 7th day after re perfusion, SOD activity was inhibited, LPO production was increased, and about 81% of CA1 cells was damaged in the mice. After being treated with KM and nimodipine, SOD activity was increased, LPO production was decreased, and importantly, pyramidal cells in hippocampal CA1 region were protected from delayed neuronal death. About 87% of pyramidal cells survived in KM group and 49% in nimodipine group. |
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| Keywords: | Kangdai Mixture Ischemic Re-perfusion LPO SOD Hippocampal CA1 Region |
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