| 参芪提取物对闭合性脑外伤作用的试验研究 |
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| 引用本文： | 李宝春. 参芪提取物对闭合性脑外伤作用的试验研究[J]. 中国实验方剂学杂志, 2007, 13(9): 41-43 |
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| 作者姓名： | 李宝春 |
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| 作者单位： | 安徽科技学院动物科学学院,安徽,凤阳,233100 |
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| 摘 要： | 目的:观察参芪提取物(SQE)对闭合性脑外伤的作用。方法:选用昆明种小鼠,随机分成模型组、脑复康(NFK)组(0.24 g.kg-1)、参芪提取物(SQE)高、中、低剂量组(0.282,0.141,0.071 g.kg-1,按公斤体重计,相当于人用量的20,10,5倍),并设正常组。采用自由落体法复制闭合性脑外伤小鼠模型,分别于造模后8,24 h测定耐缺氧时间、脑组织含水量、脑指数和血脑屏障(BBB)通透性。结果:参芪提取物能明显降低闭合性脑外伤模型小鼠脑组织含水量、脑指数和血脑屏障通透性,与模型组比较有显著性差异(P<0.05);明显提高模型小鼠耐缺氧时间,与模型组比较有显著性差异(P<0.01)。结论:参芪提取物(SQE)对小鼠闭合性脑外伤有一定的保护作用。
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| 关 键 词： | 参芪提取物 颅脑损伤 耐缺氧 伊文思蓝 血脑屏障 |
| 文章编号： | 1005-9903（2007）09-0041-03 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006-11-20 |
The Experimental Study of Shenqi Extraction on Craniocerebral Injury |
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| LI Bao-chun. The Experimental Study of Shenqi Extraction on Craniocerebral Injury[J]. China Journal of Experimental Traditional Medical Formulae, 2007, 13(9): 41-43 |
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| Authors: | LI Bao-chun |
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| Affiliation: | School of Animal Science,Anhui Science & Technology University,Fengyang,233100,China |
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| Abstract: | Objective:To observe the effects of SQE on craniocerebral injury.Methods:The mice were randomly divided into model group,NAOFUKANG(NFK)group(0.24 g·kg-1),three SQE groups(0.282,0.141,0.071 g·kg-1)and control group.The model was produced by the freely falling object.Endure time of anoxia,the content of brain water,brain index,and penetrability of blood-brain-barrier(BBB)were measured.Results:SQE can obviously decrease the content of brain water,brain index,and penetrability of BBB and improve the endure time of anoxia.Conclusion:SQE has the protective effects on craniocrebraly injury. |
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| Keywords: | SQE craniocerebral injury endure time of anoxia evans blue blood-brain-barrier |
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