Topische Anwendung von Tacrolimus bei Necrobiosis lipoidica |
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Authors: | Dr D Barth W Harth R Treudler JC Simon |
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Institution: | Klinik für Dermatologie, Venerologie und Allergologie, Universit?tsklinikum Leipzig A.?.R., Leipzig. dietrich.barth@medizin.uni-leipzig.de |
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Abstract: | Necrobiosis lipoidica (NL) is a chronic inflammatory skin disease that is difficult to treat. The etiology is unknown, but vascular abnormalities and immunologic factors have been implicated. We treated a patient with long-standing NL with multiple vascular risk factors (diabetes mellitus, protein S-deficiency, and antiphospholipid syndrome) with topical tacrolimus, a non-steroidal immunomodulator that causes no skin atrophy. After 12 weeks of topical tacrolimus (0.1%) ointment, our patient already showed a good remission with a significant decrease in inflammatory signs. |
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