| 苯妥英血药浓度监测130例/次及中毒病例分折 |
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| 引用本文： | 钱文璟,宋少刚,吴建龙,何英,陈小燕.苯妥英血药浓度监测130例/次及中毒病例分折[J].中国药房,2003,14(9):548-550. |
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| 作者姓名： | 钱文璟 宋少刚 吴建龙 何英 陈小燕 |
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| 作者单位： | 深圳市第二人民医院药剂科,深圳市,518035 |
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| 摘 要： | 目的:探讨癫痫患者苯妥英(PHT)剂量、血药浓度及疗效间的关系,为临床安全、合理应用PHT提供参考。方法:单用及合用PHT治疗癫痫70例,用荧光偏振免疫法测定PHT血清浓度130例/次。结果:常规剂量PHT治疗的个体差异极其显著,PHT血药浓度超过30μg/ml时极易引起中毒。结论:只有实时监测PHT的血药浓度并个体化给药,才能保证治疗的安全、有效。
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| 关 键 词： | 苯妥英 血药浓度 监测 中毒 |
| 文章编号： | 1001-0408(2003)09-0548-03 |
| 修稿时间： | 2003年3月25日 |
Monitoring of Serum Phenytoin Concentration in 130 Cases and Analysis of the Cases of Intoxication |
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| QIAN Wenjing,SONG Shaogang,WU Jianlong,HE Ying,CHEN Xiaoyan Dept. of Pharmacy,The Second People's Hospital of Shenzhen,Shenzhen.Monitoring of Serum Phenytoin Concentration in 130 Cases and Analysis of the Cases of Intoxication[J].China Pharmacy,2003,14(9):548-550. |
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| Authors: | QIAN Wenjing SONG Shaogang WU Jianlong HE Ying CHEN Xiaoyan Dept of Pharmacy The Second People's Hospital of Shenzhen Shenzhen |
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| Institution: | QIAN Wenjing,SONG Shaogang,WU Jianlong,HE Ying,CHEN Xiaoyan Dept. of Pharmacy,The Second People's Hospital of Shenzhen,Shenzhen 518035 |
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| Abstract: | OBJECTIVE: To study the relationship among the dosage, serum concentration and clinical effect of phenytoin
(PHT) in treating epileptic patients .METHODS: 130 steady -- state serum concentrations of PHT were determined by fluores-
cence polarization immunoassay(FPIA) in 70 patients with or without other drugs used in combination .RESULTS: The indi-
vidual difference among the patients who received routine dosage of PHT was very significant. Intoxication occurred ex-
tremely often in patients whose PHT serum concentrations were over 30μg/ml .CONCLUSION: It is necessary to perform TDM
(Therapeutic Drug Monitoring) and individualize the use of PHT,so that the safe and effective use of drug can be ensured. |
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| Keywords: | phenytoin serum concentration of drug monitoring intoxication |
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