癫患者的事件相关电位与认知功能研究

目的 :探讨癫患者事件相关电位 (ERP)与认知功能状况。方法 :对 35 0例癫患者和15 0例正常对照组进行认知功能 30题 (CCSE)、简易智力状态试验 (MMSE)和ERPP30 0 的测定。结果 :癫部分性发作者的P30 0 潜伏期比全身性发作者明显延长 ,波幅降低显著 ,认知功能测试得分也较低 ;未能分类发作患者的P30 0 潜伏期延长不明显 ,认知功能测试得分近于正常。病程 >5年者的P30 0 潜伏期较病程 1～ 5年的延长明显 ,波幅降低显著 ,认知功能测试得分也较低 ;病程 <1年者P30 0 潜伏期延长不明显 ,认知功能测试得分在正常范围。同时用三种药者的P30 0 潜伏期较同时用两种药者的延长明显 ,波幅降低显著 ,认知功能测试得分也较低 ;同时用两种药者的P30 0 潜伏期也比用一种药者明显延长 ,认知功能测试得分也较低 ;用一种药者的P30 0 潜伏期延长不明显 ,认知功能测试得分在正常范围。结论 :部分性发作患者的P30 0 潜伏期延长较全身性发作者明显 ;病程越长 ,P30 0 潜伏期延长越显著 ;多种用药患者的P30 0 潜伏期延长较用一种药者显著。

Study of event-related potenital and cognitive function in patients with epilepsy.

Objective:To study the cognitive function and event-related potential(ERP) in patients with epilepsy.Methods:Auditory ERP P 300 ,cognitive capacity screening examination(CCSE) and mini-mental state examination(MMSE) were done separately in 350 patients with epilepsy,and compared with 150 controls.Results:The latency of P 300 prolonged significantly and amplitude reduced in patients with partial seizure than those in patients with generalized seizure.Both CCSE and MMSE marks were lower.No significant difference was observed in the latency of P 300 and CCSE and MMSE between patients with unclassified seizure and control group.The latency of P 300 prolonged significantly and amplitude reduced in patients with over five years disease course than those in patients with disease course less than or equal to five years.Both CCSE and MMSE were lower.No significant difference was observed in the latency of P 300 and CCSE and MMSE between patients with disease course less than one year and control group.The latency of P 300 prolonged significantly and amplitude reduced in patients treated with three kinds of anti-eplieptic drugs than those in patients treated with two drugs,Both CCSE and MMSE marks were lower.The latency of P 300 prolonged significantly and amplitude reduced in patients treated with two kinds of anti-epileptic drugs than those with one kind of anti-epileptic drug.No significant difference was observed in the latency of P 300 and CCSE and MMSE between patients treated with one kind of anti-epileptic drug and control group.Conclusion:The latency of P 300 prolonged significantly in patients with partial seizure than those with generalized seizure.The longer the course of the disease,the more significant prolonged latency of P 300 .The latency of P 300 prolonged significantly in patients treated with several kinds of anti-epileptic drugs than those in patients treated with one drug.