| 大鼠海马多巴胺递质活动与类P300关系的探讨 |
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| 引用本文： | 李华,郑健. 大鼠海马多巴胺递质活动与类P300关系的探讨[J]. 临床神经电生理学杂志, 2001, 10(1): 32-34 |
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| 作者姓名： | 李华 郑健 |
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| 作者单位： | 第三军医大学新桥医院脑电图室, |
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| 摘 要： | 目的：探讨海马多巴胺递活动与事件相关电位类P300的关系。方法：应用立体定位技术将绝缘电极植入大鼠海马腹侧记录类P300,观察局部给予多巴胺D2受体拮抗剂sulpiride对类P300的影响。结果：海马腹侧局部注射Sulpiride30min后类P300潜伏期明显延长,2h后基本恢复正常。结论：海马腹侧多巴胺递质活动在类P300形成中起重要作用。
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| 关 键 词： | 海马 多巴胺 事件相关电位 P300 大鼠 |
Relationship between hippocampal dopamine activities and P_( 300)-like potentials in rats. |
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| Ll Hua,ZHENG jian,Dept of Neurology,Xinqiao Hospital,Third military Medical University,Chongqing. Relationship between hippocampal dopamine activities and P_( 300)-like potentials in rats.[J]. Journal of Clinical Electroneurophysiology, 2001, 10(1): 32-34 |
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| Authors: | Ll Hua ZHENG jian Dept of Neurology Xinqiao Hospital Third military Medical University Chongqing |
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| Abstract: | Objective:To observe the relation between hippocampal dopamine acivities and P 300 -like potentials in rats.Methods:The electrodes with stainless steel guide cannulae were implanted into the right ventral hippocampuses of rats by means of stereotaxic technique.Changes of ventral hippocampal P 300 -like potentials were observed by local infusion of D 2 antagonist sulpiride into the ventral hippocampuses.Results:The peak latencies of ventral hippocampal P 300 -like potentials were significantly prolonged one half an hour after infusion than that before infusion and recovered to normal level in two hours after infusion.Conclusion:Ventral hippocampal dopamine activities play an important role in generating the ventral hippocampal P 300 -like potentials in rats. [ |
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| Keywords: | Hippocampus Dopamine Event-related potentials P 300 Rat |
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