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Stability-indicating determination of adrenaline in injections containing procaine |
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| Authors: | Török I Fekete J Paál T L |
| Affiliation: | a National Institute of Pharmacy, Budapest 5, P.O.B. 450, H-1372 Hungary b Institute for General and Analytical Chemistry, Technical University, Budapest, Gellért tér 4., H-1521 Hungary |
| Abstract: | Adrenaline was determined in injections containing procaine in a 1000-fold excess by reversed-phase high-performance liquid chromatography using UV detection at 205 nm and aqueous sulphuric acid (100 μmol/l) as eluent. The relative standard deviation was 2.1%, and the method was selective in the presence of adrenaline degradation products. Changes of the capacity factor with pH and ionic strength of the eluent were studied, and a simple model is suggested to explain the retention data. |
| Keywords: | Adrenaline procaine high-performance liquid chromatography reversed-phase retention model. |
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