| 痘苗病毒增强人类白血病细胞免疫原性的实验研究 |
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| 引用本文： | 赵文然 孟德润. 痘苗病毒增强人类白血病细胞免疫原性的实验研究[J]. 哈尔滨医科大学学报, 1990, 24(6): 445-447 |
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| 作者姓名： | 赵文然 孟德润 |
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| 作者单位： | 哈尔滨医科大学微生物学教研室(赵文然，谷鸿喜，李绍贤)，哈尔滨医科大学二院内科(孟德润，王孟学)，哈尔滨医科大学二院内科(夏立娟) |
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| 摘 要： | 作者应用痘苗病毒处理人白血病细胞制备瘤苗,免疫正常615系小鼠。结果发现,实验组小鼠的NK细胞活性、白细胞介素-2(IL-2)诱生水平显著提高,T辅助细胞数及T_(11)/Ts比值显著提高(与对照组相比,P<0.01或P<0.05),未经痘苗病毒处理的人白血病细胞则无此作用。
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| 关 键 词： | 痘苗病毒 白血病细胞 免疫疗法 |
Experimental Study on Enhancement of Human leukemia Cell Immunogenicity with Vaccinia Virus |
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| Zhao Wenran et al. Experimental Study on Enhancement of Human leukemia Cell Immunogenicity with Vaccinia Virus[J]. Journal of Harbin Medical University, 1990, 24(6): 445-447 |
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| Authors: | Zhao Wenran et al |
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| Affiliation: | Department of Microbiology |
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| Abstract: | The tumor vaccine was prepared by treating human leukemia cells with vaccinia viruses, After being immunized mice of the 615 line with the tumor vaccine, the mice's splenic NK cell activity, interlukin 2 level and T cell subsets were measured. The results showed that the splenic NK cell activity, the level of interlukin2, the number of T helper and T_H/Ts(L_3T_4~+/L_Yt_2~+) ratio of the mice immnnizcd with the tumor vaccine were increased (P<0.01 or P<0.05 comparing with control). It is suggested that the immunogenicity of human leukemia cells can be enhanced by vaccinia viruses. |
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| Keywords: | Vaccinia virus Leukemia cells NK cell activity Interlukin-2 T cell subset |
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