ER、PR、CerbB-2、P53、Ki-67在乳腺癌中的表达及意义

目的 分析乳腺癌患者的临床病理特征及5种免疫组化指标表达情况的关系,探讨其临床意义.方法 采用免疫组化SP法对338例乳腺癌患者的术后石蜡标本进行ER、PR、C-erbB-2、Ki-67、P53检测,并对患者临床特征进行分析.结果 乳腺癌组织中ER、PR、C-erbB-2的阳性表达率分别为51.75%、34.9%、36.7%.P53和Ki-67的阳性表达率分别为53.8%、91.1%.肿瘤直径≤2 cm中ER、PR的阳性表达率最高(61.6%和43%).P53、ki-67的阳性表达与C-erbB-2的表达呈正相关,P53、Ki-67 的阳性表达均与ER阳性表达呈负相关.结论 乳腺癌组织中ER、PR、CerbB-2与P53、Ki-67之间有一定的联系,联合检测对乳腺癌诊断、治疗选择和预测预后有重要意义.

Expression of c-erbB-2,p53,ki-67,ER,PRand clinical significance in breast cancer

Objective To analyze the relationship between clinical pathology character and expression of five immunohistochemistry indexes in breast cancer in order to evaluate the clinical significance.Methods The immunohistochemical SP method was used to detect the expression of ER,PR,C-erbB-2,P53 and ki-67 in postoperative paraffin blocks of 338 breast cancer cases,and the positive expression rate was compared among the different subgroups.Results The positive expression rates of ER,PR,C-erbB-2,P53 and ki-67 among 338 breast cancer cases were 51.75%,34.9%,36.7%,53.80% and 91.1%.Compared with the groups with large tumors,the positive expression rates of ER and PR were both the highest in the groups with the small tumors(≤2 cm),and that of C-erbB-2 was the lowest.The expression of p53 and ki-67 was positively correlated with C-erbB-2 expression,whereas the positive expression of p53 and ki-67 was negatively correlated with ER expression.Conclusion There is a definite correlation of the expression of ER,PR,C-erbB-2 with p53 and ki-67 expression in the breast cancer tissue.Unified detection can be used to give diagnosis,choose treatment and forecast prognosis in clinical work.