清营解郁活瘀汤对营分证家兔模型血液流变学指标的影响

目的:探讨清营解郁活瘀汤对营分证家兔模型血液流变学的影响.方法:用大肠杆菌内毒素复制温病营分证家兔模型40只,随机分为药物A组(清营解都活瘀汤)、药物B组(清营养阴汤)、模型组(造模后予生理盐水)、空白对照组各10只,检测各组血液流变学、凝血功能指标的变化.结果:给药6h后,模型组有明显血液流变学改变和血液高凝,与空白对照组比较有显著性差异(P＜0.01)；清营解郁活瘀汤可显著降低营分证家兔全血黏度(低切、中切、高切)、血浆黏度,延长APTT、PT、TT时间,降低FIB水平,与模型组比较有显著性差异(P＜0.01),与空白对照组比较无统计学差异(P＞0.05)；清营解郁活瘀汤疗效优于清营养阴汤,两组比较有显著性差异(P＜0.01).结论:清营解郁活瘀汤能显著改善温病营分证家兔模型血液流变学指标及凝血功能.

Effect of Qingying Jieyu Huoyu Decoction on Hemorheology of Yingfen Syndrome Rabbit Models

Objective: To explore the effect of Qingying Jieyu Huoyu Decoction on hemorheology of yingfen syndrome model rabbits.Method: Endotoxin of Escherichia coli was used to replicate 40 yingfen syndrome rabbit models with epidemic febrile diseases,which were randomly divided into group A(Qingying Jieyu Huoyu Decoction),group B(Qingying Yangyin Decoction),model group(given saline after model-making),and blank control group,10 in each group.The index changes of hemorheology,blood coagulation function in each group were detected.Results: After administration of 6 h,the model group had significant changes of hemorheology and blood hypercoagulability,with significant difference(P<0.01) compared with the blank control group;Qingying Jieyu Huoyu Decoction could significantly reduce Yingfen syndrome rabbit′s blood viscosity(low shear,cut,cutting),plasma viscosity,prolong APTT,PT,TT time,decrease the level of FIB,with significant difference(P<0.01) compared with the model group,no significant difference(P>0.05) compared with the blank control group;Qingying Jieyu Huoyu Decoction had better effect than that of Qingying Yangyin Decoction,there were significant differences between two groups(P<0.01).Conclusion: Qingying Jieyu Decoction can significantly improve the hemorheology index and coagulation function of yingfen syndrome rabbits with epidemic febrile diseases.