侵袭性垂体腺瘤的临床病理分析

目的分析侵袭性垂体腺瘤的临床病理特征,为临床早期诊断提供依据。方法将130例垂体瘤患者分为侵袭性垂体腺瘤和非侵袭性垂体腺瘤两组,并分析比较两组的临床资料。结果侵袭性组瘤细胞高核质比、多细胞性、核异型性、出现核仁等病理形态学特征发生率明显高于非侵袭性组（均P〈0.05）;电镜观察到侵袭性组核异型及核仁边集现象。同时发现侵袭性组微血管密度表达率明显高于非侵袭性组（P〈0.05）。结论垂体腺瘤细胞病理形态学变化和微血管密度的增高对肿瘤侵袭性的诊断具有重要的参考价值,为临床早期诊断肿瘤的侵袭性提供了有价值的指标。

The clinical pathologic research of invasive pituitary adenomas

Objective To study the pathological morphologic characteristics of invasive pituitary tumor and the affect of vascularization to the tumor＇s invasion. Methods One hundred and thirty cases of pituitary adenoma patients were divided into two groups, including invasive pituitary adenomas and non-in- vasive pituitary adenomas, and the clinical data of two groups were analysed and compared. Results The difference was statistically significant between the invasive group and the non-invasive group in the in- cidence rate of pathological morphologic characteristics such as high nuclearcytoplasmic ratio, cell pleo- morphism, nuclear atypia and nucleoli appearance （P 〈 0.05 ） ; there were nuclear atypia and nucleolus margination in the invasive group through electron microscopy. And there was statistical significant differ- ence in rate of MVD expression which was higher in the invasive group than that of noninvasive group（P 〈 0.05）. Conclusion The pathological morphologic characteristics of pituitary tumor and the high ex- pression of MVD are significantly reference valuable in tumor aggression diagnosis, which provides valua- ble indicators for early clinical diagnosis of tumor invasion.