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Association between SARS-CoV-2 infections during pregnancy and preterm live birth |
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| Authors: | Sarita Mohanty Alan T. Tita Michael Varner Melissa S. Stockwell Gabriella Newes-Adeyi Ashley N. Battarbee Lawrence Reichle Tyler Morrill Michael Daugherty Mirella Mourad Raul A. Silverio Francisco Kate Woodworth Kristina Wielgosz Romeo Galang Pete Maniatis Vera Semenova Fatimah S. Dawood |
| Affiliation: | 1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA;2. Center for Women's Reproductive Health and Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA Contribution: Conceptualization (equal), Investigation (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal);3. Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA Contribution: Conceptualization (equal), Investigation (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal);4. Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA;5. Abt Associates, Rockville, Maryland, USA Contribution: Conceptualization (equal), Data curation (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal);6. Abt Associates, Rockville, Maryland, USA Contribution: Data curation (equal), Validation (equal), Writing - review & editing (equal);7. Centers for Disease Control and Prevention, Atlanta, Georgia, USA Contribution: Data curation (equal), Validation (equal), Writing - review & editing (equal);8. Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA Contribution: Investigation (equal), Writing - review & editing (equal);9. Centers for Disease Control and Prevention, Atlanta, Georgia, USA Contribution: Writing - review & editing (equal);10. Centers for Disease Control and Prevention, Atlanta, Georgia, USA Contribution: Data curation (equal), Project administration (equal), Writing - review & editing (equal);11. Centers for Disease Control and Prevention, Atlanta, Georgia, USA Contribution: Investigation (equal), Writing - review & editing (equal);12. Centers for Disease Control and Prevention, Atlanta, Georgia, USA Contribution: Conceptualization (equal), Data curation (equal), Funding acquisition (equal), Methodology (equal), Project administration (equal), Supervision (equal), Validation (equal), Writing - original draft (equal), Writing - review & editing (equal) |
| Abstract: | We examined associations between mild or asymptomatic prenatal SARS-CoV-2 infection and preterm live birth in a prospective cohort study. During August 2020–October 2021, pregnant persons were followed with systematic surveillance for RT-PCR or serologically confirmed SARS-CoV-2 infection until pregnancy end. The association between prenatal SARS-CoV-2 infection and preterm birth was assessed using Cox proportional-hazards regression. Among 954 pregnant persons with a live birth, 185 (19%) had prenatal SARS-CoV-2 infection and 123 (13%) had preterm birth. The adjusted hazard ratio for the association between SARS-CoV-2 infection and preterm birth was 1.28 (95% confidence interval 0.82–1.99, p = 0.28), although results did not reach statistical significance. |
| Keywords: | COVID-19 pregnancy premature birth SARS-CoV-2 |