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A meta-review of the impact of compression therapy on venous leg ulcer healing |
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| Authors: | Declan Patton Pinar Avsar Aicha Sayeh Aglecia Budri Tom O'Connor Simone Walsh Linda Nugent Denis Harkin Niall O'Brien Jonathan Cayce Michael Corcoran Mario Gaztambide Zena Moore |
| Affiliation: | 1. Skin Wounds and Trauma Research Centre, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland School of Nursing and Midwifery, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland Fakeeh College of Medical Sciences, Jeddah, Saudi Arabia School of Nursing and Midwifery, Griffith University, Southport, Queensland, Australia Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia;2. Skin Wounds and Trauma Research Centre, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland;3. Skin Wounds and Trauma Research Centre, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland School of Nursing and Midwifery, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland Fakeeh College of Medical Sciences, Jeddah, Saudi Arabia;4. The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Dublin, Ireland;5. The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland;6. DeRoyal Industries, Knoxville, Tennessee, USA;7. DeRoyal International, Dublin, Ireland |
| Abstract: | This meta-review aimed to appraise and synthesise findings from existing systematic reviews that measured the impact of compression therapy on venous leg ulcers healing. We searched five databases to identify potential papers; three authors extracted data, and a fourth author adjudicated the findings. The AMSTAR-2 tool was used for quality appraisal and the certainty of the evidence was appraised using GRADEpro. Data analysis was undertaken using RevMan. We identified 12 systematic reviews published between 1997 and 2021. AMSTAR-2 assessment identified three as high quality, five as moderate quality, and four as low quality. Seven comparisons were reported, with a meta-analysis undertaken for five of these comparisons: compression vs no compression (risk ratio [RR]: 1.55; 95% confidence interval [CI] 1.34-1.78; P < .00001; moderate-certainty evidence); elastic compression vs inelastic compression (RR: 1.02; 95% CI: 0.96-1.08; P < .61 moderate-certainty evidence); four layer vs |
| Keywords: | compression bandages compression therapy healing meta-review venous leg ulcers |