Idiopathic ventricular fibrillation associated with long-coupled Purkinje ectopy |
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| Authors: | Elodie Surget MD Josselin Duchateau MD James Marchant PhD Philippe Maury MD Richard Walton PhD Thomas Lavergne MD PhD Estelle Gandjbakhch MD PhD Antoine Leenhardt MD Fabrice Extramiana MD PhD Michel Haïssaguerre MD PhD |
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| Affiliation: | 1. IHU Liryc, Electrophysiology and Heart Modeling Institute, Foundation Bordeaux Université, Bordeaux, France;2. Cardiology Department, Rangueil University Hospital, Toulouse, France;3. Cardiology Department, Rhythmology Unit, Hôpital Européen Georges Pompidou, Paris, France;4. Institute of Cardiology, Pitié-Salpêtrière University Hospital, Paris, France;5. Université de Paris Cité, CNMR, Maladies Cardiaques Héréditaires Rares, APHP Hôpital Bichat, Paris, France;6. IHU Liryc, Electrophysiology and Heart Modeling Institute, Foundation Bordeaux Université, Bordeaux, France Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France |
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| Abstract: | Introduction Idiopathic ventricular fibrillation (IVF) is mainly associated with and triggered by short-coupled (R-on-T) ventricular ectopics. However, little is known about the risk of VF associated with long-coupled premature ventricular complexes (LCPVCs). Objective To examine the prevalence and characteristics of IVF patients presenting with LCPVCs. Methods Consecutive patients with IVF and PVCs from five arrhythmia referral centers were reviewed. We included patients presenting LCPVCs, defined as PVCs falling after the end of the T wave, with a normal QTc interval. We evaluated demographics, medical history, and clinical circumstances associated with PVCs and VF episodes. The origin of PVCs was determined by invasive mapping. Results Seventy-nine patients with IVF were reviewed. Among them, 12 (15.2%) met the inclusion criteria (8 women, age 36 ± 14 years). Eleven patients had documented LCPVCs initiating repetitive PVCs or sustained VF, whereas 1 had only documented isolated PVCs. In 10 of 12 patients, PVCs were recorded showing both long and short coupling intervals of 418 ± 46 and 304 ± 33 ms, respectively. Mapping showed that PVCs originated from the left Purkinje in 10 patients, from the right Purkinje in 1 patient, and both in 1 patient. Compared to other patients from the initial cohort, IVF with LCPVCs was associated with a left-sided origin of PVCs (92% in long-coupled IVF vs. 46% of left Purkinje PVCs in short-coupled IVF, p = .004). Conclusion Long-coupled fascicular PVCs, traditionally recognized as benign, can be associated with IVF in a subset of patients. They can induce IVF by themselves or in association with short-coupled PVCs. |
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| Keywords: | catheter ablation idiopathic ventricular fibrillation long-coupled PVC Purkinje sudden death |
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