Effects of Levodopa on Postural Strategies in Parkinson's disease |
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| Affiliation: | 1. Department of Electrical, Electronic and Information Engineering “Guglielmo Marconi”, University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy;2. Veterans Affairs Portland Health Care System, 3710 SW Us Veteran Hospital Rd, Portland, OR 97239, USA;3. Department of Neurology, School of Medicine, Oregon Health & Science University, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USA;1. Sports Equipment and Technology, Technische Universität Chemnitz, Germany;2. Division of Physiotherapy, Stellenbosch University, South Africa;3. Human Locomotion, Technische Universität Chemnitz, Germany;1. Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic;2. Department of Rehabilitation and Sport Medicine, 2nd Faculty of Medicine, University Hospital Motol, Charles University in Prague, Prague, Czech Republic;1. University of Toronto, Rehabilitation Sciences Institute, 500 University Avenue, Toronto, ON M5G 1V7, Canada;2. University of Toronto, Department of Physical Therapy, 500 University Avenue, Toronto, ON M5G 1V7, Canada;3. Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada;4. Toronto Rehabilitation Institute, 550 University Avenue, Toronto, ON M5G 2A2, Canada;5. University of Manitoba, Faculty of Kinesiology and Recreation Management, 102 Frank Kennedy Centre, Winnipeg, MB R3T 2N2, Canada;6. Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada;1. IRIS Team—Physiopathologie de la Vision et Motricité Binoculaire, CNRS FR3636 Neurosciences, UFR Biomédicale, Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France;2. Association À la Découverte de l’Âge Libre (ADAL), 9 rue Edouard Pailleron, 75019 Paris, France |
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| Abstract: | Altered postural control and balance are major disabling issues of Parkinson's disease (PD). Static and dynamic posturography have provided insight into PD's postural deficits; however, little is known about impairments in postural coordination. We hypothesized that subjects with PD would show more ankle strategy during quiet stance than healthy control subjects, who would include some hip strategy, and this stiffer postural strategy would increase with disease progression.We quantified postural strategy and sway dispersion with inertial sensors (one placed on the shank and one on the posterior trunk at L5 level) while subjects were standing still with their eyes open. A total of 70 subjects with PD, including a mild group (H&Y≤2, N = 33) and a more severe group (H&Y≥3, N = 37), were assessed while OFF and while ON levodopa medication. We also included a healthy control group (N = 21).Results showed an overall preference of ankle strategy in all groups while maintaining balance. Postural strategy was significantly lower ON compared to OFF medication (indicating more hip strategy), but no effect of disease stage was found. Instead, sway dispersion was significantly larger in ON compared to OFF medication, and significantly larger in the more severe PD group compared to the mild. In addition, increased hip strategy during stance was associated with poorer self-perception of balance. |
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| Keywords: | Parkinson's disease Levodopa Postural strategy |
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