| Imaging mass spectrometry: a molecular microscope for studying the role of lipids in Parkinson's disease |
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| 作者姓名： | Vinata Vedam-Mai Jacob M.Samuel Boone M.Prentice |
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| 作者单位： | 1. Department of Neurology, University of Florida;2. Department of Chemistry, University of Florida |
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| 摘 要： | <正>Parkinson’s disease–A lipidopathy? The histopathological hallmark of Parkinson’s disease(PD) and dementia with Lewy bodies are inclusions enriched in α-synuclein(α-syn), known as Lewy bodies, which are not only composed of proteins, but also a core of lipid species. PD has been thus far principally thought of as a “proteinopathy” caused by the misfolding of α-syn. However,
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