Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy |
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| Authors: | Forough Alemi,Fatemeh Sadeghsoltani,Khashayar Fattah,Parisa Hassanpour,Faezeh Malakoti,Sina Kardeh,Melika Izadpanah,Debora Aparecida Pires de Campos Zuccari,Bahman Yousefi,Maryam Majidinia |
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| Affiliation: | 1. Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Central Clinical School, Monash University, Melbourne, Australia;4. Molecular Investigation of Cancer Laboratory (MICL), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil;5. Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran |
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| Abstract: | Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. A huge number of studies have mentioned the significant role of ncRNAs in cancer prevention and therapy that make them an interesting subject for cancer therapy. However, there are several limitations, including delivery, uptake, and short half-life, in the application of ncRNAs in cancer treatment. Exosomes are introduced as promising options for the delivery of ncRNAs to the target cells. In this review, we will briefly discuss the application and barriers of ncRNAs. After that we will focus on exosome-based ncRNAs delivery and their advantages as well as the latest achievements in drugging ncRNAs with exosomes. |
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| Keywords: | Evs, extracellular vesicles exosomes miRNA ncRNAs ncRNAscancer |
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