| 阿尔茨海默病与轻度认知障碍弥散张量成像研究 |
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| 引用本文： | 吴婷,刘文,肖朝勇.阿尔茨海默病与轻度认知障碍弥散张量成像研究[J].临床精神医学杂志,2009,19(4). |
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| 作者姓名： | 吴婷 刘文 肖朝勇 |
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| 作者单位： | 放射科,南京医科大学附属脑科医院,210029 |
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| 基金项目： | 南京市卫生局资助项目(编号:ZKM06059) |
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| 摘 要： | 目的:应用磁共振弥散张量成像技术(DTI)研究阿尔茨海默病(AD)与轻度认知障碍患者(MCI)脑白质损伤情况。方法:对21例AD患者、15例MCI患者和20名健康志愿者进行脑部DTI扫描后,测量双脑区感兴趣区的各向异性分数值(FA)且进行比较。结果:AD患者额叶、顶叶、颞叶和胼胝体的FA值与MCI组和对照组均存在显著性差异,MCI患者仅颞叶和胼胝体的FA值与对照组均存在显著性差异。结论:AD患者与MCI患者存在脑白质结构的差异,DTI技术能够在一定程度上提供MCI的早期诊断指标。
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| 关 键 词： | 阿尔茨海默病 轻度认知障碍 弥散张量成像 |
Study of diffusion tensor imaging in patients with Alzheimer disease and mild cognitive impairment |
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| WU Ting,LIU Wen,XIAO Chao-yong.Study of diffusion tensor imaging in patients with Alzheimer disease and mild cognitive impairment[J].Journal of Clinical Psychological Medicine,2009,19(4). |
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| Authors: | WU Ting LIU Wen XIAO Chao-yong |
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| Institution: | WU Ting,LIU Wen,XIAO Chao-yong.Department of Radiology,Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective:To investigate the white matter integrity in patients with Alzheime disease(AD)and mild cognitive impairment(MCI)by using magnetic resonance diffusion tensor imaging.Method:21 AD patients,15 MCI patients and 20 healthy volunteers received diffusion tensor imaging.Fractional anisotropy(FA)in white matter were measured and compared in the interest regions respectively.Results:There were significant differences in frontal lobe,parietal lobe,temporal lobe and corpus callosum between patients with AD a... |
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| Keywords: | Alzheimer disease mild cognitive impairment diffusion tensor imaging |
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