Prostaglandin E2 and F2 alpha levels in the duodenal and antral mucosa of non-ulcer dyspeptic and duodenal ulcer patients |
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Authors: | M C Parodi M Marugo G Ciancamerla R Santucci L Fazzuoli |
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Institution: | Dept. of Gastroenterology, S. Martino Hospital, Genoa, Italy. |
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Abstract: | In the present study we evaluated the contents of endogenous prostaglandins type E2 and F2 alpha in the antral mucosa, and the type E2 in the duodenal mucosa in a group of thirty non-ulcer dyspeptics in comparison with a group of thirty duodenal ulcer patients. A significantly reduced concentration of duodenal and antral PGE2 was found in ulcer patients as compared with dyspeptic subjects. A significantly increased concentration of antral PGE2 was observed in cases with active superficial antral gastritis, either in dyspeptics or in duodenal ulcer patients, as compared with normal antrum cases. A significantly increased level of PGF2 alpha was found in active superficial gastritis of the dyspeptic group. |
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