基底细胞癌亚临床侵袭范围

目的：观察基底细胞癌（BCC）的镜下浸润特点;探讨BCC亚临床侵袭范围的临床预测指标。方法：采集显微镜下包括完整肿瘤的病理切片,观察BCC在镜下的微观表现;分别记录肿瘤直径的宏观测量值和微观测量值,并进行二者的相关性分析。结果：肿瘤直径的微观测量值小于18 mm的基底细胞癌,在表皮下向周边浸润,侵袭局限且多呈不对称表现,深度多不超过深筋膜,其直径的微观测量值（Y）与宏观测量值（X）间存在直线相关：Y=1.5 9 0＋0.998X（mm）,回归系数β的95%CI（0.861,1.135）,R2=0.84。结论：BCC的亚临床侵袭局限,多呈不对称性,直径≤18 mm的BCC,其直径的微观测量值与宏观测量值间存在直线相关关系,或可作为BCC亚临床侵袭范围的预测指标,仍需进一步临床证实。

The subclinical invasive extension of basal cell carcinoma

Objective ：A survey was performed for the feature of subclinical invasive extension of basal cell carci noma （BCC） under microscope. Then the prediction of subclinical invasive extension was discussed. Methods ：Pathological sections including complete tumor microscopically were selected and measured. The feature of tumors was described and diameter of tumor was measured microscopically and macroscopically,then correlation between the microscopic and macroscopic diameter was analyzed. Results ：As for BCC tumor with diameter less than 18 mm ,the invasion of tumor has a feature of localization and dissymmetry. The depth seldom exceed deep fascia. Linear correlation exists between microscopic diameter （Y） and macroscopic diameter （X） of tumor. Regression equation ： Y = 1. 590 ＋ 0. 998X （mm）, 95% CI of 13（0. 861,1. 135）, R2 = 0. 84. Conclusion： Subclinical invasion of BCC is local and dissymmetric, There is linear correlation between microscopic diameter and macroscopic diameter of tumor. Diameter of BCC maybe considered as an index of subclinical extensive invasion but needs more clinical confidence.