The concept of crosstalk‐directed embryological target mining and its application to essential hypertension treatment failures |
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| Authors: | Alan Alper Sag MD Oguzhan Sal MD Yagmur Kilic MD Emine Meltem Onal MD Mehmet Kanbay MD |
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| Affiliation: | 1. Division of Interventional Radiology, Department of Radiology, Koç University School of Medicine, Istanbul Turkey ; 2. School of Medicine, Koç University, Istanbul Turkey ; 3. Division of Nephrology, Department of Internal Medicine, Koç University School of Medicine, Istanbul Turkey |
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| Abstract: | This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug‐resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician‐directed fashion. |
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| Keywords: | denervation hypertension, essential hypertension resistant to conventional therapy radiology, interventional |
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