Relationship between kidney findings and systemic vascular damage in elderly hypertensive patients without overt cardiovascular disease |
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Authors: | Giulio Geraci MD Giuseppe Mulè MD Gabriella Paladino MD Marta Maria Zammuto MD Antonella Castiglia MD Emilia Scaduto MD Federica Zotta MD Calogero Geraci MD Antonio Granata MD Pasquale Mansueto MD Santina Cottone MD |
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Affiliation: | 1. Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Nephrology and Hypertension, European Society of Hypertension Excellence Center, University of Palermo, Palermo, Italy;2. Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Geriatrics, University of Palermo, Palermo, Italy;3. “San Giovanni di Dio” Hospital, Unit of Nephrology and Dialysis, Agrigento, Italy |
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Abstract: | Few studies have investigated the influence of age on the relationships between systemic vascular damage, kidney dysfunction, and intrarenal hemodynamic changes in patients with hypertension without overt cardiovascular disease. The authors enrolled 126 elderly patients with hypertension (aged ≥65 years) and 350 nonelderly patients with hypertension (aged <65 years). Carotid intima‐media thickness, renal resistive index, and aortic pulse wave velocity were performed in all patients. Elderly patients with hypertension had lower estimated glomerular filtration rates and higher albuminuria, renal resistive index, carotid intima‐media thickness, and aortic pulse wave velocity compared with nonelderly patients with hypertension (P < .001). Carotid intima‐media thickness independently correlated with renal resistive index and estimated glomerular filtration rate in nonelderly patients with hypertension, whereas it was significantly related to renal resistive index only in elderly patients with hypertension. Aortic pulse wave velocity was independently associated with albuminuria in nonelderly patients with hypertension, whereas it did not independently correlate with any indexes of renal damage in elderly patients with hypertension. Age is an important modifier of the relationships between renal function and renal hemodynamics with subclinical vascular involvement in elderly persons without cardiovascular disease. |
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Keywords: | Hypertension Elderly Renal disease Vascular disease Renal haemodyanmics Systemic vascular damage |
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