Enhanced production of interferon-gamma by T lymphocytes cloned from rejected kidney grafts. |
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| Authors: | R Benvenuto A Bachetoni P Cinti F Sallusto A Franco E R Molajoni V Barnaba F Balsano R Cortesini |
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| Affiliation: | Fondazione Andrea Cesalpino, I Clinica Medica, II Patologia Chirurgica, Università La Sapienza, Roma, Italy. |
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| Abstract: | Seventy-seven T cell clones were generated from cell blasts infiltrating rejected kidney allografts. All clones, either CD4 or CD8, displayed cytolytic activity evaluated by lectin-dependent cell-mediated cytotoxicity (LDCC) and natural killer activities. Furthermore, both types of clones were able to produce IFN-gamma following PHA stimulation. These data suggest that the graft infiltrate is characterized by T cell clones with cytolytic potential responsible for the killing of graft cells. The production of IFN-gamma, enhancing the class II MHC expression, may amplify the recipient immune response. |
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