Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids |
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| Authors: | J. D. Pickard V. Walker L. Brandt S. Zygmunt J. Smythe |
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| Affiliation: | (1) Academic Neurosurgical Unit, University of Cambridge, UK;(2) Clinical Neurological Sciences Group, University of Southampton, UK;(3) Department of Clinical Biochemistry, University of Southampton, UK;(4) University Department of Neurosurgery, Lund, Sweden;(5) Department of Neurosurgery, University Hospital of Northern Sweden, Umea, Sweden |
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| Abstract: | Summary CSF eicosanoid levels are raised following subarachnoid haemorrhage but not sufficiently to be vasoactive per se within the cerebral circulation. Rebleeding and intraventricular haemorrhage are two factors associated with a worse outcome after aneurysmal SAH. We have examined the effects of these two factors on the CSF levels of TXB2 (TXA2 metabolite), PG 6-keto F1 (prostacyclin metabolite), PGF2 and PGE2 in 44 patients following subarachnoid haemorrhage. In 15 patients who had received no non-steroidal antiinflammatory agent or dexamethasone, intraventricular haemorrhage increased the median levels of all four eicosanoids in ventricular CSF by 2.1–5.1-fold. In 4 patients who rebled, the CSF median levels of all four eicosanoids were raised up to 250-fold over the normal range. These concentrations are just sufficient to have cerebrovascular and neuromodulatory effects. |
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| Keywords: | Cerebrospinal fluid eicosanoids prostaglandins subarachnoid haemorrhage thromboxane |
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