| 肿瘤坏死因子在猴急性胰腺炎中的作用及生长抑素的治疗效果 |
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| 引用本文： | 杨植,杨志英,唐伟松,赵平.肿瘤坏死因子在猴急性胰腺炎中的作用及生长抑素的治疗效果[J].中国普外基础与临床杂志,1996(1). |
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| 作者姓名： | 杨植 杨志英 唐伟松 赵平 |
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| 作者单位： | 承德医学院附属医院普外科，北京协和医院基本外科 |
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| 摘 要： | 作者采用猴制作急性坏死性胰腺炎（ＡＮＰ）模型，观察肿瘤坏死因子（ＴＮＦ）以及生长抑素对猴ＡＮＰ血浆ＴＮＦ和猴死亡情况的影响。结果发现：猴ＡＮＰ早期其血浆ＴＮＦ明显升高，与猴死亡呈平行关系；生长抑素可明显降低ＴＮＦ含量，使猴死亡率下降，存活时间延长。提示ＴＮＦ是ＡＮＰ早期的重要炎症介质，生长抑素可明显抑制炎症反应过程，对猴ＡＮＰ有确切的治疗效果。
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| 关 键 词： | 猴，肿瘤坏死因子，急性坏死性胰腺炎，生长抑素 |
EFFECT OF TUMOR NECROSIS FACTOR ON ACUTE NECROTIZING PANCREATITIS OF MONKEYS AND THERAPEUTIC EFFECT OF STILAMIN |
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| Yang Zhi, Yang Zhiying, Tang Weisong,et al..EFFECT OF TUMOR NECROSIS FACTOR ON ACUTE NECROTIZING PANCREATITIS OF MONKEYS AND THERAPEUTIC EFFECT OF STILAMIN[J].Chinese Journal of Bases and Clinics In General Surgery,1996(1). |
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| Authors: | Yang Zhi Yang Zhiying Tang Weisong |
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| Abstract: | In the early stage of acute necrotizing pancreatitis (ANP) of experimental monkeys,the concentration of tumor necrosis factor(TNF) in blood was significantly increased. Stilamin could significantly reduce the level of TNF,decrease the mortality,and prolong the survival time of monkeys. The authors draw the conclusion that TNF is an important inflammatory media in the early stage of ANP. Stilamin can significantly inhibit the inflammatory process and has good effect in the treatment of ANP in experimental monkeys. |
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| Keywords: | Monkey Tumor necrosis factor Acute necrotizing pancreatitis Stilamin |
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