维生素D与复发性流产的病因学机制研究进展

复发性流产（RSA）的发生率逐年提高，严重威胁了女性的生殖健康，随着国家三孩政策的开放，生育需求也随之升高，但RSA病因学机制错综复杂，至今仍有50%病因不明。随着研究的深入，发现维生素D（VD）在女性生殖疾病中起到重要作用，RSA患者普遍存在VD缺乏的情况，VD水平的下降会导致流产风险升高。VD与遗传、感染、血栓前状态、内分泌及免疫都具有相关性，直接或间接参与RSA的发病。该文就VD与RSA的病因学机制研究作一综述。

Advances in the etiological role of vitamin D in recurrent spontaneous abortion

The incidence of recurrent spontaneous abortion (RSA) is increasing year by year, which severely threatens women''s reproductive health. With the implementation of the three-child policy in China, there has been an increase in the demand for births. However, due to the intricate etiological mechanisms of RSA, 50% of the cases are still agnogenic. Further studies have revealed an essential role of vitamin D (VD) in female reproductive system diseases, while VD deficiency is prevalent among RSA patients. As the level of VD declines, the risk of abortion increases. VD is related to heredity, infection, prethrombotic state, and endocrine and immune processes, and directly or indirectly participates in the pathogenesis of RSA. In this review, the etiological role of VD in RSA is discussed and summarized.