| 实验性运动病大鼠脑细胞c-fos基因表达 |
| |
| 引用本文： | 王琰,董文度,袁驾南,徐根兴,金淑仪,姜正林,李建成,庄坚. 实验性运动病大鼠脑细胞c-fos基因表达[J]. 南京军医学院学报, 1998, 0(1) |
| |
| 作者姓名： | 王琰 董文度 袁驾南 徐根兴 金淑仪 姜正林 李建成 庄坚 |
| |
| 作者单位： | 海军医学高等专科学校细胞生物学研究室!南京，210099，海军医学高等专科学校细胞生物学研究室!南京，210099，海军医学高等专科学校细胞生物学研究室!南京，210099，海军医学高等专科学校细胞生物学研究室!南京，210099，南通医学院航海医学研究所!南通，226001，南通医学院航海医学研究 |
| |
| 摘 要： | 取SD大鼠16只分为两组，其中一组按Crampton的方法进行旋转刺激诱导运动病；而另一非旋转组作为对照。用原位杂交和免疫组化方法、图像分析技术对旋转刺激组大鼠及对照组大鼠大脑皮质、脑干和小脑皮质中c-fosmRNA、Fos蛋白含显变化进行定位、定量研究。结果表明，旋转刺激后三种组织中c-fosmRNA、Fos蛋白的含量均有增加．推测应激反应基因c－fos的表达参与运动病的发生和发展。
|
| 关 键 词： | 运动病 c-fos基因 Fos蛋白 脑组织 |
Expression of c-fos Gene in Brain Tissues of Rats by Experimental Motion Sickness |
| |
| Wang Yan, Dong Wendu, Yuan Jia''''nan, Xu Genxing. Expression of c-fos Gene in Brain Tissues of Rats by Experimental Motion Sickness[J]. Journal of Nanjing Military Medical College, 1998, 0(1) |
| |
| Authors: | Wang Yan Dong Wendu Yuan Jia''''nan Xu Genxing |
| |
| Abstract: | Sixteen rats(Sprague-Dowley) were equally divided into two groups: the experiment group(MSG) with motion sickness induced by Crampton's method and the control group (CG) without motion Sickness. A localization and quantification study on changes of levels of c-fos and Fos protein in cerebral cortex, brain stem and cerebellar cortex was carried out in rats of MSG and CG, by means of in situ hybridization, immunohistochemical analysis and image analysis. The result showed that the levels of c-fos and Fos protein in brain tissues we examined increased in rats of MSG after stimulation of rotation. It was suggested that the expression of c-fos gene in stress state involve in the process of motion sickness. |
| |
| Keywords: | motion sickness c-fos gene Fos protein brain tissue |
| 本文献已被 CNKI 等数据库收录！ |
