Studies on the synthesis andin vitro anti-tumor activity of dihydroberberine derivatives |
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| Authors: | In Jong Kim Yea Jin Park Joo il Kim Kyung Tae Lee Sin Kyu Kim |
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| Affiliation: | College of Pharmacy, Kyung Hee University, Hoeki-Dong, Dongdaemoon-Ku, 130-701, Seoul, Korea. |
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| Abstract: | Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell. |
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