In vivo metabolism of alpha-methyltryptamine in rats: identification of urinary metabolites |
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| Authors: | Kanamori T Kuwayama K Tsujikawa K Miyaguchi H Iwata Y T Inoue H |
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| Affiliation: | National Research Institute of Police Science, Kashiwa, Chiba, Japan. kanamori@nrips.go.jp |
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| Abstract: | 1. The in vivo metabolism of alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were administered 10 mg kg(-1) AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid-liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS). 3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1'-hydroxy-AMT were detected as metabolites of AMT. |
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