参七汤对冠心病支架植入术后再狭窄的影响和机制探讨

目的观察参七汤时冠心痛支架植入术后再狭窄的影响，并探讨其作用机制。方法冠心痛支架植入术后患者68例，随机分为参七汤治疗蛆（治疗组，35例）和常规处理组（对照组，33例）。随访6个月，观察再狭窄发生率、血小板活化标志物CD62P和炎症反应指标超敏C-反应蛋白（h—CRP）。结果治疗组再狭窄率为14．29％低于对照组的36．36％（P〈0．05）。PCI术后，CD62P和hs—CRP显著升高，加用参七汤治疗后，CD62P和hs—CRP水平较对照组明显降低（P〈0．01）。6个月后，血瘀证计分治疗组显著低于对照组（P（0．01）。结论参七汤能有效减少冠心病PCI术后再狭窄的发生，减少斑块炎症反应，降低血小板活化水平，是其预防PCI术后再狭窄的机制之一。

The Effect Mechanism of Shenqi Decoction on Restenosis after Implantation of Stents in Coronary Artery Disease

Objective To observe the effect of Shenqi Decoction on restenosis （RS） after implantation of stents in patients （pts） with coronary artery disease. Methods Sixty - eight pts with coronary artery disease after implantation of stents were randomly divided into two groups ： Shenqi Decoction group （n=35） and control group （n=33）. The RS rate,CD62P,high sensitive - and C - reactive protein （hs - CRP） wete studied, The effect of Shenqi Decoction was evaluated by scores of blood - stasis syndrome. Results The incidence of RS rate in Shenqi Decoction group was lower than that in the control group （P〈0. 05）. The level of CD62P and hs -CRP was significantly higher after percutaneous coronary intervention. After treatment with Shenqi Decoction, the level of CD62P and hs - CRP in Shenqi Decoction group was obviously degraded than that in control group （P〈0.01）. The blood - stasis syndrome scores in Shenqi Decoction group were significantly lower compared with that in control group after treatment for 6 months. Conclusion The Shenqi Decoction could effectively reduce the occurrence of restenosis. It might be due to reduce the inflammation reaction of plaque and to degrade the level of platelet activation.