疏血通注射液联合前列地尔治疗老年椎-基底动脉供血不足

目的观察疏血通注射液联合前列地尔治疗老年频发椎-基底动脉供血不足（VBI）的临床疗效。方法90例老年患者随机分为疏血通组、前列地尔组，联合组。10d为1个疗程。观察临床疗效、血浆纤维蛋白原和平均血流速度的变化。结果联合组有效率为93.33％，高于疏血通纽（P〈0．05），明显优于前列地尔组（P〈0．01）。疏血通组与联合组均明显降低纤维蛋白原，与治疗前比较有统计学意义（P〈0．01）；联合组较单用前列地尔组降低纤维蛋白原明显（P〈0．05），无脑梗死发生。治疗后各组平均血流速度明显加快，与治疗前比均有统计学意义（P〈0.01）。结论老年人频发VBI时联合应用疏血通和前列地尔可达到协同互补的治疗效果，优于单用疏血通或前列地尔的治疗效果。

The Effect of Shuxuetong Injection with Alprostadil for Treatment of Vertebrobasilar Artery Insufficiency

Objective To study the therapeutic effect of Shuxuetong injection with alprostadit for treatment of vertebrobasilar artery insufficiency （VBI）, Methoth Ninety patients （pts） with VBI were randomly divided into the Shuxuetong injection group （n=30）, alprostadil group （n=30） and combination group （n= 30） treated with respective medicine on the base of routine treatment for 10 days. The clinical efficacy, the changes of the plasma fibrinogen and the average blood flow rates were tested and compared. Results The cure rates in combination group （93.33 % ） was higher than that in Shuxuetong injection group and the alprostadil group （P〈0.05 and P〈0.01）. The plasma fibtinogen was decreased significantly in the Shuxuetong group and the combination group （P〈0.01）. The plasma fibrinogen in the combination group was lower than that in the alprostadil group （P〈0.05）. The average blood flow rates were improved slgnificantly in all groups （P〈0.01）. Conclusion Shuxuetong injection with alprostadil had obvious therapeutic effect on VBI,and its effect was better than that by Shuxuetong injection or alprostadil.