MMP-9和VEGF的表达对非小细胞肺癌预后价值的评估

目的检测基质金属蛋白酶-9（MMP-9）和血管内皮生长因子（VEGF）在非小细胞肺癌组织中的表达，并评估其预后价值。方法应用免疫组织化学技术检测86例非小细胞肺癌和60例正常肺组织中MMP-9和VEGF的表达，分析其在不同临床特征中的价值，关注其表达对判断预后的意义。结果非小细胞肺癌中MMP-9和VEGF表达的阳性率明显高于正常肺组织，MMP-9和VEGF的表达与非小细胞肺癌肿瘤的直径、胸膜侵犯、分化程度及淋巴结转移有关，非小细胞肺癌中MMP-9和VEGF的表达呈正相关，生存分析显示MMP-9和VEGF的表达与患者的预后有关。结论非小细胞肺癌中MMP-9和VEGF高表达，MMP-9可能对肿瘤的血管形成有促进作用，联合检测MMP-9和VEGF的表达可能与非小细胞肺癌患者的预后有关。

Expression and significance of MMP-9 and VEGF in non-small cell lung carcinoma

Objective To investigate the protein expressions of MMP-9 and VEGF,observe their relationship and clinical significance on development and metastasis of non-small cell lung carcinoma.Methods We detected the protein expressions of MMP-9 and VEGF by IHC in the non-small cell lung carcinoma(86 cases) and normal lung tissues(60 cases).Their expression relationship and different pathological characters in the non-small cell lung carcinoma were analyzed.Results The protein expressions of MMP-9 and VEGF were higher in the neoplasm than in normal lung tissues.Their expressions were correlated with diameter,pleura invasion,differentiation and lymph node metastasis.Positive correlation between MMP-9 and VEGF protein were found in neoplasm.The expressions of MMP-9 and VEGF were correlated with prognosis.Conclusion The higher expressions of MMP-9 and VEGF are found in non-small cell lung carcinoma.The combined detection of MMP-9 and VEGF may be helpful for prognosis of neoplasm.