Usefulness of MMP-9/TIMP-1 in Predicting Tumor Recurrence in Patients Undergoing Curative Surgical Resection for Gastric Carcinoma |
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Authors: | Yeon Seok Seo Jong-Jae Park Ji Hoon Kim Jin Yong Kim Jong Eun Yeon Jae Seon Kim Kwan Soo Byun Young-Tae Bak |
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Institution: | (1) Department of Internal Medicine, Korea University Medical Center, Guro Hospital, Seoul, Korea;(2) Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea;(3) Gurodong-gil 97, Guro-gu, Seoul, 152-703, Korea |
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Abstract: | Degradation of the extracellular matrix is an essential step in tumor invasion and metastasis. It involves the actions of
matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). We evaluated the expression of MMP-9
and TIMP-1 in gastric carcinomas and the relationship between this expression and tumor recurrence. Eighty patients who had
undergone curative surgical resection for gastric carcinoma were included. Resected gastric tissue samples were stained immunohistochemically
to evaluate the expression of MMP-9 and TIMP-1. TIMP-1 expression was related to the depth of tumor invasion and lymph node
metastasis. The proportion of tumors larger than 5 cm, or displaying muscle layer invasion, and the cumulative incidence of
tumor recurrence were significantly elevated in patients with tumors expressing TIMP-1. Furthermore, these measures were lowest
in patients with no TIMP-1 expression and highest in patients who only expressed TIMP-1. In conclusion, TIMP-1 expression
and the balance between expression of MMP-9 and expression of TIMP-1 may be important indicators of tumor progression and
predictors of tumor recurrence. |
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Keywords: | Gastric cancer Neoplasm recurrence Matrix metalloproteinases Tissue inhibitor of metalloproteinases |
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