癌高发区非癌症患者血清铜、锌水平及影响因素

目的：探讨癌高发区非癌症患者的血清铜、血清锌水平及其影响因素。方法：用原子吸收法测定血清铜、血清锌值。并对膳食、健康状况和经济水平等因素进行问卷调查，采用单因素相关、逐步回归分析方法来研究癌高发区、对照区年龄在40～60岁长期居住的非癌症患者人群及其多种因素影响的关系。结果：癌高发区人群血清铜、血清铜锌比值明显高于对照区，血清锌值明显低于对照区。血清铜值与现病史和地区有关．男性血清铜高于女性，血清锌值随经济水平和肉摄入量的增加而增高。地区、现病史和性别对血清铜锌比值影响比其它因素更明显。结论：现病史和地区是影响血清铜锌比值的重要因素。血清铜锌比值可考虑作为评价癌高发区的因素之一。

Analysis of the Concentrations of Blood Copper, Zinc and Their Related Factors among Non-Cancer Patients in High Cancer Incidence Areas

Objective:To explore the relationship between blood serum copper and zinc concentrations and their affecting factors among non cancer patients in high cancer incidence areas.Methods:The blood serum copper and zinc concentrations were measured by Atomic Absorbtion Sectrophotometr(AAS).The dietary and health status,social economical factors were investigated by questionnaire among permnent residents aged 40-60 years both in high cancer incidence areas and low cancer areas(as control).All data were analysised to explore the relationship by single factor correlation and stepwise regression methods.Results:The concentration of serum copper and ratio of Cu/Zn in serum in high cancer incidence areas are higher than those in control area,while that of serum zinc in high cancer incidence areas is lower compared with control. The concentration of serum copper is related with current disease history and residential area.The serum zinc concentration in male is higher than that in female,followed by an increase in economic level and daily meat intake, and the serum zinc concentration is also increased.Region difference,current disease history and sex have more remarkable effect on the ratio of serum Cu/Zn than other factors.Conclusion:The current disease history and region difference are the key factors affecting the ratio of serum Cu/Zn,which can be used as one of the indicators to evealuate higher incidence of cancer.