国产泮托拉唑与进口奥美拉唑预防应激性溃疡的疗效及成本效果分析

目的:观察国产泮托拉唑与进口奥美拉唑预防应激性溃疡的疗效以及成本-效果比较。方法:52例应激性溃疡高危病人随机分为泮托拉唑与奥美拉唑2组,分别予泮托拉唑或奥美拉唑40 mg,加入氯化钠注射液100 mL中静脉滴注,12 h 1次。每4 h记录病人胃液pH值,同时每日记录病人胃液、呕吐物及粪便潜血试验结果,分析每组的疗效及成本-效果比。结果:泮托拉唑组与奥美拉唑组胃液pH值≥4的百分比分别为46．4％和49．0％,应激性溃疡的发生率分别为11％和17％,2组相比均无显著差异(P＞0．05);而泮托拉唑组成本-效果比为6．5,明显低于奥美拉唑组(11．5)。结论:国产泮托拉唑与进口奥美拉唑预防应激性溃疡具有相同的疗效,前者成本明显降低。国产泮托拉唑是预防应激性溃疡的一个安全、经济而又有效的方法。

Therapeutic effects and cost-profit analysis between domestic pantoprazole and imported omeprazole in prevention of stress ulcer

AIM:To compare therapeutic effects and cost-profit between domestic pantoprazole and imported omeprazole.METHODS:Fifty-two patients with high risk of stress ulcer were randomly divided into pantoprazole and omeprazole groups.Each group was respectively given 40 mg pantoprazole or omeprazole individually dissolved in sodium chloride injection 100 mL,q12 h by intravenous infusion,with recording of gastric pH value every 4 h,and simultaneously of occult blood tests for gastric juice,vomitus and stool everyday.Finally the therapeutic effects and the ratio of cost-profit for the two groups were analyzed.RESULTS: The gastric pH values above 4 in pantoprazole and omeprazole groups were 46.4 % and 49.0 % respectively anti the frequencies of stress ulcer were 11% and 17% respectively with no statistically significant difference between them(P＞0.05).The cost-profit ratio was 6.5/11.5 for the pantoprazole and omeprazole groups.CO- NCLUSION:Domestic pantoprazole and imported omeprazole possess same therapeutic effect in preventing stress ulcer but the former is much lower in price and also as well as for safety.