化痰安神熄风法治疗高血压病临床疗效及其对生化指标的影响

目的观察化痰安神熄风法对痰湿壅盛型高血压病患者临床疗效及生化指标的影响。方法选取符合纳入标准的高血压病患者100例,采用简单随机化原则分为治疗组、对照组(各50例)。对照组采用西医常规治疗,治疗组采用西医常规治疗加中医化痰安神熄风法(自拟化痰安神熄风方)治疗,2组治疗时间均为60d。观察治疗前后2组痰湿壅盛证积分、血压、心率、血脂、尿酸、空腹血糖、空腹胰岛素、C反应蛋白的变化,并进行比较。结果治疗后治疗组与对照组的血压均有改善,治疗组的血压改善优于对照组(收缩压、舒张压治疗后组间比较,P值分别为0.000、0.049);治疗组的心率较对照组明显改善(P=0.000);空腹血糖、空腹胰岛素、C反应蛋白均较对照组明显改善(P值分别为0.001、0.000、0.000);与本组治疗前比较差异有统计学意义(P=0.000)。结论在西医常规治疗的基础上,化痰安神熄风法能更好改善痰湿壅盛型高血压病患者的血压和心率,降低C反应蛋白水平,并可能对血脂、尿酸有一定的改善作用。

Clinical Efficacy of Therapeutic Method of Eliminating Phlegm, Tranquilizing and Calming Wind on Essential Hypertension and Influence on Biochemical Parameters

Objective To observe the clinical efficacy of therapeutic method of eliminating phlegm, tranquilizing and calming wind on essential hypertension （EH） with accumulation of phlegm-wetness and influence on biochemical parameters. Methods One hundred cases of EH were selected and randomly divided into the treatment group and the control group （50 cases for each group）. The two groups were given the same western treatment. The therapeutic method of eliminating phlegm, tranquilizing and calming wind （with recipe of eliminating phlegm, tranquilizing and calming wind） was given to the treatment group additionally. The course of treatment was 60 days. Grade of phlegm-wetness syndrome, blood pressure （BP）, rhythm of the heart （HR）, blood lipid, uric acid （UA）, blood-glucose, fasting insulin and C-reactive protein of the two groups before and after treatment were observed and compared. Results BP in the two groups were improved after treatment, and BP in the treatment group was improved more than that in the control group （SBP P=0.000, DBP P =0.049）. HR in the treatment group was improved notably than that in the control group （P = 0.000）. After treatment, the blood-glucose, fasting insulin and C-reactive protein in the treatment group were improved notably compared with those in the control group （the former P=0.001, the latter two P=0.000）. UA, TC, LDL-C and HDL-C in the treatment group after treatment were improved in comparison with those before treatment （P=0.000）. Conclusion On the basis of western treatment, the therapeutic method of eliminating phlegm, tranquilizing and calming wind can improve BP, HR and C-reactive protein in the patients of EH with accumulation of phlegm-wetness, and it can probably improve the blood lipid and UA to some extent.