陕西汉族PCI术后人群CYP2C19基因多态性分析

目的 描述陕西省汉族PCI术后人群的细胞色素2C19(CYP2C19)基因型分布特征。方法 采用个体化基因诊断芯片技术对1 220例陕西汉族PCI术后人群进行CYP2C19基因分型检测。结果 陕西汉族术后人群中男性野生基因型比例为34.02%（*1*1）,突变杂合子基因型比例为33.61%（*1*2和1*3）,突变纯合子基因型比例为9.43%（*2*2、*2*3和*3*3）。女性野生基因型比例为9.34%（*1*1）,突变杂合子基因型比例为11.23%（*1*2和1*3）,突变纯合子基因型比例为2.38%（*2*2、*2*3和*3*3）。 结论 陕西汉族PCI术后人群CYP2C19基因多态性以野生型纯合子*1*1和突变杂合子*1*2为主。

Genetic polymorphism analysis of CYP2C19 in Shaanxi Han population after percutaneous coronary intervention

AIM To study the characteristics of CYP2C19 genotype in Shaanxi Han population after percutaneous coronary intervention (PCI) and establish a foundation for individualized treatment. METHODSGenotyping of CYP2C19 in 1 220 Shaanxi Han patients after PCI were determined by gene chip. RESULTSAccording to genotyping results, the frequencies of wild type (WT) *1*1 in Shaanxi Han population were 34.02%, WT *1*2 and *1*3 were 33.61%, and WT *2*2, *2*3 and *3*3 were 9.43% in males. The frequencies of WT *1*1 were 9.34%, WT *1*2 and *1*3 were 11.23%, and WT *2*2, *2*3 and *3*3 were 2.38% in females. CONCLUSIONGenetic polymorphism analysis of CYP2C19 WT *1*1 and *1*2 in Shaanxi Han population after PCI are most frequent.