色素上皮细胞衍生因子在代谢综合征中的研究进展

代谢综合征（MS）是代谢层面的心血管危险因子的聚集现象，主要包括高血压、血脂异常、糖尿病、胰岛素抵抗及腹部肥胖等。近年来MS发病率明显上升并严重危害居民的身体健康。色素上皮细胞衍生因子(PEDF)属丝氨酸蛋白酶抑制基因家族，是由多种细胞表达，具有多种生物学活性的分泌性糖蛋白。近年来多项临床试验提示PEDF参与了MS的发生发展，是一个有希望的疾病治疗靶点。本文就PEDF在MS中的作用综述。

Recent progress of pigment epithelium-derived factor in metabolic syndrome

Metabolic syndrome (MetS) is a constellation of multiple metabolic risk factors including hypertension, dyslipidemia, glucose intolerance, insulin resistance and abdominal obesity. Over the past decades, the prevalence of MetS has increased dramatically, imposing a devastating and pandemic health threat. Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein belonging to the superfamily of serine protease inhibitors produced from a variety of tissues. Cuulative studies have demonstrated that PEDF plays a pivotal role in the etiology of MetS. The present review focuses on the critical roles of PEDF in the development of MetS and the mechanisms behind them.