乳腺癌基因分型与血清肿瘤标志物表达的相关性分析

目的 探讨乳腺癌基因分型与血清肿瘤标志物之间的相关性。方法 选取2013年1月-2015年12月的106例乳腺癌患者，免疫组化检测ER、PR、c-erbB-2，采用电化学发光法对肿瘤标志物进行检测，单因素方差分析是否存在显著性差异。结果 细胞角蛋白十九片段、铁蛋白、癌胚抗原、糖类抗原724在Luminal A型乳腺癌组血清中有较高水平的表达，明显高于其他3种基因分型，差异有统计学意义（P<0.05）；糖类抗原125、糖抗原153在Luminal A型和Basal-like型乳腺癌组血清中有较高水平的表达，明显高于另2种基因分型，差异有统计学意义（P<0.05）；其他肿瘤标志物在不同基因分型中差异无统计学意义。结论 乳腺癌患者血清中细胞角蛋白十九片段、铁蛋白、癌胚抗原、糖类抗原724、糖类抗原125、糖类抗原153水平与乳腺癌基因型有相关性。

Correlation Analysis Between Genotyping of Breast Cancer and Expression of Serum Tumor Markers

OBJECTIVE To investigate the correlation between genotyping of breast cancer and blood serum tumor markers. METHODS The serum tumors markers were examined by electrochemistry illumination and radioimmunoassay in 106 patients with breast cancer from January 2013 to December 2015, ER, PR and c-erbB-2 were detected by immunohistochemistry. Tumor markers were detected by electrochemiluminescence, one-way ANOVA was used to decide significant differences in categories. RESULTS Increase of serum CYFRA21-1, FER, CEA, CA724 level was correlated with Luminal A, significantly higher than the other 3 genotyping, the difference was statistically significant(P<0.05). CA125, CA153 level was correlated with Luminal A and Basal-like, significantly higher than the other 2 genotyping, the difference was statistically significant (P<0.05). There were no significant differences in other tumor markers in different genotypes. CONCLUSION CYFRA21-1, FER, CEA, CA724, CA125, CA153 level in breast cancer have correlation with genotyping.