| 乙肝病人外周血T细胞亚群和mIL-2R表达水平的研究 |
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| 引用本文： | 王克霞,朱玉霞,许礼发,杨庆贵. 乙肝病人外周血T细胞亚群和mIL-2R表达水平的研究[J]. 中国基层医药, 2002, 9(7): 589-591 |
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| 作者姓名： | 王克霞 朱玉霞 许礼发 杨庆贵 |
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| 作者单位： | 232001,淮南,安徽理工大学医学院 |
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| 基金项目： | 安徽省科技成果鉴定 ( 2 0 0 0 115 ) |
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| 摘 要： | 目的：探讨乙型病毒性肝炎病人外周血T淋巴细胞亚群和膜白介素－2受体（mIL-2R）表达水平及其在乙肝发病机制中的作用。方法：用生物素－链霉亲和素法对196例乙肝病人外周血单个核细胞进行T细胞亚群及植物血凝素（PHA）诱导前后mIL-2R的检测。结果：乙肝病人外周血T淋巴细胞亚群和单个核细胞mIL-2R表达水平降低，与正常对照相比，差异有显著意义（P＜0．01）。结论：乙肝病人体内存在明显的细胞免疫功能紊乱，T细胞活化障碍，并与肝病的慢性化有关。
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| 关 键 词： | 乙型肝炎 膜白介素－2受体 T细胞亚群 外周血单个核细胞 细胞免疫功能 |
| 修稿时间： | 2002-04-09 |
The expression level of T cell subsets and mIL-2R on surface of PBMC of patients with hepatitis B |
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| WANG Kexia,ZHU Yuxia,XU Lifa,et al.. The expression level of T cell subsets and mIL-2R on surface of PBMC of patients with hepatitis B[J]. Chinese Journal of Primary Medicine and Pharmacy, 2002, 9(7): 589-591 |
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| Authors: | WANG Kexia ZHU Yuxia XU Lifa et al. |
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| Affiliation: | WANG Kexia,ZHU Yuxia,XU Lifa,et al.Medical College,Anhui University of Science & Technology,Anhui,232001,China |
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| Abstract: | Objective To study the level of T cell subsets and membrane interleukin 2 receptor(mIL 2R) on surface of peripheral blood mononuclear cells(PBMC) of the patients with hepatitis B and its role in the pathogenesis of hepatitis B.Methods The level of T cell subsets and mIL 2R before and after being induced by PHA were detected with biotin streptatividin technique for 196 cases of hepatitis B.Results The expressive level of T cell subsets and mIL 2R before and after being induced by PHA were all lower in the patients with hepatitis B than that in normal controls(P<0.01).Conclusion The function of cellular immunity,the levels of mIL 2R and activation of T cells are obviously in disorder in patients with hepatitis B,and were closely associated with the chronicity of the patients with hepatitis B. |
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| Keywords: | Hepatitis B membrane interleukin 2 receptor(mIL 2R) T cell subsets peripheral blood mononuclear cells(PBMC) |
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