慢性充血性心力衰竭大鼠模型的建立

目的：探讨建立慢性充血性心力衰竭大鼠模型的方法。方法：通过结扎大鼠左冠状动脉造成大面积心肌梗死。术后8周，进行血流动力学、心室质量指数检测及心肌标本留取。结果：术后大鼠出现明显的心肌梗死改变。血流动力学提示大鼠MBP下降，LVSP，±dp／dt显著下降，LVEDP明显升高。大鼠心室质量指数增加。光镜下大鼠心肌梗死区心肌纤维明显，心肌梗死边缘心肌排列紊乱、心肌细胞肥大，核增大，部分细胞可有核固缩。结论：结扎左冠状动脉可成功制造慢性心力衰竭大鼠模型，对心力衰竭的实验研究有益。

Study on Establishing Rat Model With Chronic Congestive Heart Failure

Objective：To establish a rat model with chronic congestive heart failure. Methods： Left coronary ar tery was ligated to induce left heart failure after extensive myocardial infarction in rats. Changes of hemodynamics, ventricular mass index and cardiac muscle pathologic changes were observed 8 weeks after operation. Results.. Myo eardial infarction was induced successfully in rats. Cardiac function parameters including MBP, LVSP,± dp/dt were reduced and LVEDP was elevated significantly. Ventricuiar mass index were increased. Light microscopic examination showed there were proliferation of fibrous tissue, hypertrophic cardiomyocyte and nuclear pycnosis in certain cells on border of ventricular infarction border zone. Conclusion： Left coronary artery ligation can ideally induce rat model with chronic congestive heart failure, and it＇s of great importance for the research of heart failure.