Stereoselectivity of L-baclofen in hippocampal slices of the rat |
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| Authors: | H L Haas R W Greene H R Olpe |
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| Affiliation: | 1. Neurochirurgische Universitätsklinik, CH-8901 Zürich, Switzerland;2. Biology Research Laboratories, Ciba-Geigy AG, CH-4002 Basel Switzerland |
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| Abstract: | Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 microM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the L- none in the D-enantiomer. D-BF did not antagonize the action of L-BF. |
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| Keywords: | hippocampal slice baclofen stereoselectivity rat |
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