| 接触抗癌药物对人体细胞DNA稳定性的影响 |
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| 引用本文： | 王丽卿,游文风,齐华,宋国英,陈勇夫,蔡婷.接触抗癌药物对人体细胞DNA稳定性的影响[J].郑州大学学报(医学版),1989(1). |
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| 作者姓名： | 王丽卿 游文风 齐华 宋国英 陈勇夫 蔡婷 |
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| 作者单位： | 河南医科大学生物学教研室
(王丽卿，游文风，齐华，宋国英，陈勇夫)，郑州市第四人民医院儿科(蔡婷) |
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| 摘 要： | 本文应用姊妹染色单体互换(SCE)和染色体畸变(CA)的方法,观察了长期接触化学抗癌药物的护理人员和肿瘤研究人员的淋巴细胞变化,以估价接触抗癌药物对人体DNA稳定性的影响,共30例。结果表明:接触者的SCE值比非接触者高,(P<0.01)。其染色体畸变值也比非接触者显著增高,(P<0.01)。这就说明抗癌药物能诱发SCE和染色体畸变并使其比率显著增高,本文并进一步探讨了SCE值的变化和染色体畸变的可能机理以及环境暴露程度对SCE值的影响。
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| 关 键 词： | 姊妹染色单体互换 抗癌药 DNA 损伤 |
DNA stability in human cells-Disturbed by exposure to anticancer drugs |
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| Wang Liqing et al.DNA stability in human cells-Disturbed by exposure to anticancer drugs[J].Journal of Zhengzhou University: Med Sci,1989(1). |
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| Authors: | Wang Liqing |
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| Institution: | Wang Liqing et al Department of Biology |
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| Abstract: | Lymphocytes sampled from the nurses working in tumour wards and the research workers tumour have been analyzed with oeytogenetic methods of sister-chroma-tid exchanges (SCE) and chromosome aberrations (CA) to detect the DNA stabil-ity in them. Thirty cases have been inspected. It has been found out thatsister-chromatid exchanges (SCE) and chromosome aberrations (CA) are related tofrequent exposure to a anticancer drugs. The SCE and CA values of the personnelkeeping touch with anticancer drugs are significantly higher than those out oftouch with them (P<0.01). It is shown that anticancer drugs can induce SCEand CA, and raise their odds ratios significantly. In this article, the possible mechanism about the changes of the SCE value and chromosome aberrations,and the influence of the degree of ambient surroundings exposure on SCEvalue are discussed. |
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| Keywords: | sister-chromatid exchanges anticancer drugs DNA injury |
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