Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats |
| |
| Authors: | Melly S Oitzl Marc Fluttert E.Ron de Kloet |
| |
| Affiliation: | Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medical Pharmacology, University of Leiden, P.O. Box 9503, 2300 RA Leiden, Netherlands |
| |
| Abstract: | Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into the dorsal hippocampus dose-dependently improved the performance of male Wistar rats in the water maze 24 h after treatment. This observation suggests a discrete specificity of hippocampal glucocorticoid receptors in facilitation of memory. |
| |
| Keywords: | Corticosteroid Glucocorticosteroid receptor Hippocampus Facilitation Learning and memory Rat |
| 本文献已被 ScienceDirect 等数据库收录！ |
